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Funding and publications

Current funding

  • 1R01HL112639-01 (Ramchandran, R.) 2012-2016 - NIH/NHLBI. Targeting DUSP-5 to treat vascular anomalies - Role: PI
  • 1R01HL123338-01A1 (Ramchandran, R.) 2015-2019 - NIH/NHLBI.  Delta like-4 long non-coding RNA function in angiogenesis and vascular anomalies - Role:  PI
  • 1R01HL128374-01 (Sampath, V.) 2016-2021 - NIH/NHLBI. Inflammatory angiogenesis in the developing lung - Role:  Co-I
  • 1R01HL120585 (Mukherjee, P. and Ramchandran, R.) 2013-2018 - NIH/NHLBI. Cystathionine beta synthase (CBS) and angiogenesis - Role: Co-I
  • 1R01HL108938-01 (Miao, R. and Ramchandran, R.) – 2011-2016 - NIH/NHLBI. Role of NgBR - Role: Co-I
  • 2R01HL033833-29 (Harder, D and Ramchandran, R.) 2014-2019 - NIH/NHLBI. Astrocyte Secretome: Ability to modify phenotype and genotype of cells within CNS - Role: Co-I

Publications (2010-present)

    1. Wickramasekera N, Gebremedhin D, Carver K, Vakeel P, Ramchandran R, Schuett A and Harder D.  Role of dual-specificity protein phosphatase-5 (DUSP-5) in modulating myogenic response in rat cerebral arteries. J. Appl Physiol. 2013 Jan 15;114(2):252-61.  PMCID: PMC3544499.
    2. Kilari S, Remadevi I, Zhao B, Miao Q, Ramchandran R, North PE, Rahimi N and Wilkinson GA.  Endothelial cell-specific chemotaxis receptor (ECSCR) enhances vascular endothelial growth factor (VEGF) receptor-2/kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR.  J Biol Chem.  2013 Apr 12;288(15):10265-74.  PMCID:  PMC3624410.
    3. Span EA, Goodsell DS, Ramchandran R, Franzen M, Hemran T and Sem DS.  Protein structure in context: The molecular landscape of angiogenesis.  Biochem Mol Biol Educ. 2013 Jul-Aug;41(4):213-23.  PMCID: PMC4074543.
    4. Leigh NR, Schupp MO, Li K, Vakeel P, Gastonguay A, Wang, L, Chun CZ, Wilkinson GA and Ramchandran R.  Mmp17b and its putative substrate Reck are essential for neural crest migration in vivo. PLoS One. 2013 8(10):e76484.  PMCID: PMC3788140.
    5. Wang L, Cossette SM, Rarick KR, Gershan J, Dwinell MB, Harder DR and Ramchandran R.  Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS One. 2013 Dec 4;8(12):e80933.  PMCID: PMC3851470.
    6. Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP and Li X.  SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.  Hum Mol Genet. 2014 Mar 15;23(60): 1644-55. PMCID: PMC3929098.
    7. Sampath V and Ramchandran R.  (2014) Translational Research – It Takes Two to Tango! MOJ Cell Sci Report. 1(1): 00003.
    8. Schupp MO, Waas M, Chun CZ and Ramchandran R.  Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development.  Dev. Biol.  2014 Sep 1;393(1): 71-83. PMCID: PMC4137469.  
    9. Rajasimha HK, Prasannakumar BS, Ramamoorthy P, Hegde M, Barde S, Chandru V, Ravinandan ME, Ramchandran R, Haldar K, Lin JC, Babar IA, Girisha KM, Srinivasan S, Navaneetham D, Battu R, Devarakonda R, Kini U, Vijayachandra K, Verma IC. Organization for Rare Diseases India (ORDI) – Addressing the Challenges and Opportunities for Indian Rare Disease Patients.  Genet. Res. 2014 Aug 13; 96:e009. PMID 25579084.
    10. Cossette SM, Gastonguay A, Bao X, Lerch-Gaggl A, Zhong, L, Harmann LM, Koceja C, Miao, RQ, Vakeel P, Chun C, Li K, Foeckler J, Bordas M, Weiler H, Strande J, Palecek SP and Ramchandran RSucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.  Biol. Open. 2014 Dec 12;4(1):48-61.  PMCID: PMC4295165.
    11. Nayak J, Gastonguay A, Talipov MR, Padmanabhan P, Span E, Kutty R, Jensen D, Pokkuluri P, Sem DS*, Rathore R* and Ramchandran R*.  Protein expression, characterization and activity comparisons of wild type and mutant DUSP5 proteins.  BMC Biochemistry. 2014 Dec 18;15(1):27. PMCID: PMC4299175. 
    12. Menden H, Welak S, Cossette S, Ramchandran R and Sampath V. LPS-mediated Angiopoietin-2 dependent autocrine angiogenesis is regulated by Nox2 in human pulmonary microvascular endothelial cells. J. Biol. Chem. 2015 Feb 27;290(9): 5449-61. PMCID: PMC4342461.
    13. Sampath V, Menden H, Helbling D, Gastonguay A, Li K, Tschannen MR, Worthy EA, Ramchandran R and Dimmock DP.  SIGIRR genetic variants in premature infants with necrotizing enterocolitis. Pediatrics. 2015 Jun;135(6):e1530-4. doi: 10.1542/peds.2014-3386. PMID: 25963006. PMCID: PMC4444800
    14. Li K, Chowdhury T, Vakeel P, Koceja C, Sampath and Ramchandran R.  Delta-like4 mRNA is regulated by adjacent natural antisense transcripts.  Vasc. Cell. 2015 Mar 24;7:3. doi: 10.1186/s13221-015-0028-9. eCollection 2015 PMCID:  PMC4409748.
    15. Hoeppner LH, Sinha S, Wang Y, Bhattacharya R, Dutta S, Gong X, Bedell VM, Suresh S, Chun CZ, Ramchandran R, Ekker SC and Mukhopadhyay D.  RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells.  Journal of Cell Sci. 2015 Oct 1;128(19):3556-68. doi: 10.1242/jcs.167601. Epub 2015 Jul 1. PMID: 26136364. PMCID: PMC4647168.
    16. Ladisa J, Bozdag S, Olson J, Ramchandran R, Kersten J and Eddinger T.  Gene expression in experimental aortic coarctation and repair: candidate genes for therapeutic intervention.  PLoS ONE.  2015 Jul 24;10(7):e0133356. doi: 10.1371/journal. pone.0133356. eCollection 2015. PMID: 26207811. PMCID: PMC4514739.
    17. Neumann TS, Span EA, Kalous KS, Bongard R, Gastonguay A, Lepley MA, Kutty RG, Nayak J, Bohl C, Lange RG, Sarker MI, Talipov MR, Rathore R*, Ramchandran R* and Sem DS*.  Identification of inhibitors that target dual-specificity phosphatase 5 provides new insights into the binding requirements for the two phosphate pockets.  BMC Biochemistry. (2015)16:19 DOI 10.1186/s12858-015-0048-3. PMID: 26286528. PMCID: PMC4545774.
    18. Kilari S, Cossette S, Pooya S, Bordas M, Huang YW, Ramchandran R* and Wilkinson GA*. Endothelial cell surface expressed chemotaxis and apoptosis regulator (ECSCR) regulates lipolysis in white adipocytes via the PTEN/AKT signaling pathway.  PLoS One.  2015 Dec 21;10(12):e0144185. Doi:  10.1371/journal.pone.0144185. eCollection 2015. PMID: 26692198.  PMCID:  PMC4686900.
    19. Rana U, Liu Z, Kumar SN, Zhao B, Wu W, Bordas M, Cossette S, Szabo S, Foeckler J, Weiler H, Chrzanowska-Wodnicka M, Holtz ML, Misra RP, Salato V, North P, Ramchandran R* and Miao QR*. Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. Dev. Biol. 2015 Dec 31. pii: S0012-1606(15)30038-5. doi: 10.1016/j.ydbio.2015.12.023. PMID:  26746789.
    20. Palen K, Weber J, Dwinell M, Johnson B, Ramchandran R and Gershan J.  E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells.  Oncotarget.  2016 May 30. doi: 10.18632/Oncotarget.9715. PMID: 27270319.
    21. Iden M, Fye S, Li K, Chowdhury, Ramchandran R and Rader JS.  The lncRNA PVT1 Contributes to the Cervical Cancer Phenotype and Associates with Poor Patient Prognosis.  PLoS ONE.  2016 May 27;11(5):e0156274. doi: 10.1371/journal.pone.0156274. PMID: 27232880.
    22. Talipov MR, Nayak J, Lepley M, Bongard RD, Sem DS, Ramchandran R*, and Rathore R*.  Critical role of the secondary binding pocket in modulating enzymatic activity of DUSP5 towards phosphorylated ERKs.  Biochemistry.  2016 Oct. 14. doi: 10.1021/acs.biochem.6b00498.  PMID:  27739308.
    23. Cossette SM, Bhute V, Bao X, Hermann LM, Sonin DL, Horswill MA, Sinha I, Gastonguay A, Pooya S, Bordas M, Kumar SN, Mirza SP, Palecek SPP, Strande J and Ramchandran R. Sucrose non-fermenting related kinase mediated Rho-Associated Kinase signaling is responsible for cardiac function. Circ Cardiovasc Genet.  2016 Oct. 25. doi:  10.1161/Circgenetics.116.001515.  PMID:  27780848.
    24. Kutty RG, Xin G, Schauder D, Cossette SM, Bordas M, Cui W* and Ramchandran R*.  Dual specificity phosphatase 5 is required for T cell survival in mammals.  PLoS ONE.  2016 In Press.

*Denotes Joint First Author or Corresponding Author

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